Randolph diet type 11 diabetes
Foster-Schubert, David R. Wadden, Thomas A. Adobe Flash Player is required to view this feature. Reviews in Endocrine and Metabolic Disorders 17:1, 81-90. Karamat, K. Greenway. Journal of Diabetes and its Complications 30:2, 212-220. (2016) Translation of the Diabetes Prevention Program to Ethnic Communities in the United States. , M. Alfaiate, D. Michael Lincoff, Angel Rodriguez, Lei Chen, Yongming Qu. 2017. First occurrences of primary and secondary outcomes in the two groups were compared with hazard ratios and 95% confidence intervals. (2017) Effect of a Long-Term Intensive Lifestyle Intervention on Cognitive Function: Action for Health in Diabetes Study. 2017. Jacobs, D. Heymsfield, Steven B. (2016) The Type 2 Diabetic Heart: Its Role in Exercise Intolerance and the Challenge to Find Effective Exercise Interventions. (2016) Severe hypoglycemia in the Look AHEAD Trial. Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. (2017) Physical Activity in Obese Type 2 Diabetes After Gastric Bypass or Medical Management. CrossRef 134 Chunsong Hu, Qinghua Wu. CrossRef 69 Matti Uusitupa. CrossRef 147 Jayanti Mukherjee, Catarina Sternhufvud, Nancy Smith, Kelly Bell, Marni Stott-Miller, Donna McMorrow, Stephen Johnston. Diabetes in Native Populations and Underserved Communities in the USA. Cummings. Adobe Flash Player is required to view this feature. (2016) Macrovascular and microvascular disease in obese patients with type 2 diabetes attending structured diabetes education program: a population-based propensity-matched cohort analysis of Patient Empowerment Programme (PEP). If you are using an operating system that does not support Flash, we are working to bring you alternative formats. In subsequent years, the frequency was reduced to one session annually. Patel, A. (2017) Obesity and kidney disease: Hidden consequences of the epidemic. Huten, T. org. Give monthly to improve the lives of people with diabetes. 4 years, when the last observed event occurred. Endocrinology and Metabolism Clinics of North America 45:3, 581-604. (2016) Association of Weight Loss Maintenance and Weight Regain on 4-Year Changes in CVD Risk Factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. B. Moore. Endocrinology and Metabolism Clinics of North America 45:3, 553-564. None of the corporate supporters, listed below, had any role in the trial design, data analysis, or reporting of results. Petersen, P. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2017) Obesity and kidney disease: hidden consequences of the epidemic. C. (2016) Exercise resistance across the prediabetes phenotypes: Impact on insulin sensitivity and substrate metabolism. Optimal Nutrition for the Older Adults. We have considered several possible explanations for the lack of a significant difference in the rates of cardiovascular events between groups. Diabetes support and education featured three group sessions per year focused on diet, exercise, and social support during years 1 through 4. Hansen, Per L. (2016) Genetics of cardiovascular and renal complications in diabetes. A toolbox of strategies was available for patients having difficulty achieving the weight-loss goals (see the Supplementary Appendix ). (2016) Association Between Weight Change, Clinical Outcomes, and Health Care Costs in Patients with Type 2 Diabetes. (2016) Relationship between body weight and the increment in serum brain-derived neurotrophic factor after oral glucose challenge in men with obesity and metabolic syndrome. Iglicki, F. G. Cardiovascular Risk Factors: Hypertension. Adobe Flash Player is required to view this feature. Reed, Andrew L. (2017) Effects of Longitudinal Glucose Exposure on Cognitive and Physical Function: Results from the Action for Health in Diabetes Movement and Memory Study. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Adobe Flash Player is required to view this feature. CrossRef 111 David Berrigan, Richard P Troiano, Barry I Graubard. (2016) Investigational glucagon-like peptide-1 agonists for the treatment of obesity. Tsai, Henry A. Clark, Kimberly A. (2016) Clinical Outcomes of Metabolic Surgery: Efficacy of Glycemic Control, Weight Loss, and Remission of Diabetes. CrossRef 89 Jens Jordan, Hermann Toplak, Guido Grassi, Volkan Yumuk, Vasilios Kotsis, Stefan Engeli, Cesare Cuspidi, Peter M. Another possibility is that a sustained weight loss of more than that achieved in the intervention group may be required to reduce the risk of cardiovascular disease. Adobe Flash Player is required to view this feature. Castellino, F. Virani, Emanuele Di Angelantonio, David Wormser. 3 years among patients with type 2 diabetes who had undergone bariatric surgery. We performed analyses of primary and secondary outcomes using time-to-event methods according to the intention-to-treat principle, as prespecified in the protocol. Adobe Flash Player is required to view this feature. Bell, Alain G. CrossRef 130 Yijun Chen, Leonor Corsino, Prapimporn Chattranukulchai Shantavasinkul, John Grant, Dana Portenier, Laura Ding, Alfonso Torquati. CrossRef 132 Anthony S. (2017) Vascular risk in obesity: Facts, misconceptions and the unknown. CrossRef 153 Soo Lim, Seon Mee Kang, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Hee Hwang, Hye Seung Jung, Kyong Soo Park, Jun Oh Ryu, Hak Chul Jang. , a hazard ratio of 0. (2017) Preoperative Fasting Plasma C-Peptide Levels as Predictors of Remission of Type 2 Diabetes Mellitus after Bariatric Surgery: A Systematic Review and Meta-Analysis. The use of antihypertensive medications, statins, and insulin was lower in the intervention group than in the control group (Fig. Association of an intensive lifestyle intervention with remission of type 2 diabetes. 7 years, 60% of the patients were women, and the mean body-mass index was 36. The between-group difference in cardiovascular risk factors diminished over time, with the glycated hemoglobin level and systolic blood pressure showing the most sustained differences. Adobe Flash Player is required to view this feature. Media in This Article Figure 1 Changes in Weight, Physical Fitness, Waist Circumference, and Glycated Hemoglobin Levels during 10 Years of Follow-up. Phillips. 9 to 10. Additional eligibility criteria are described elsewhere 6 and in the Supplementary Appendix. Adobe Flash Player is required to view this feature. Supported by the National Institutes of Health (NIH) and other Department of Health and Human Services agencies through cooperative agreements with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, and DK56992). CrossRef 121 J. Robert, E. CrossRef 102 Rachelle Gandica, Phil Zeitler. C. Catizone, C. Brancati, M. D. Pouderoux, N. 1 (SAS Institute). Hajage, S. Adobe Flash Player is required to view this feature. Lichtenstein. CrossRef 73 Jessica E Middlemiss, Carmel M McEniery. M. 3), and less than 4% of all patients randomly assigned to a study group had been lost to follow-up. 12 When the intervention was stopped on September 14, 2012, the median follow-up was 9. Adobe Flash Player is required to view this feature. Zelle, Gerald Klaassen, Edwin van Adrichem, Stephan J. One possibility is that the study lacked sufficient power. CrossRef 55 Vlado Perkovic, Rajiv Agarwal, Paola Fioretto, Brenda R. Via, Jeffrey I. (2016) Exercise in Patients on Dialysis: A Multicenter, Randomized Clinical Trial. Lam. Bariatric Surgery Improves Type 2 Diabetes Mellitus. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. 2017. The intervention may also have had different effects in different subgroups. g. CrossRef 23 Jennifer Panosian, Su-Ann Ding, Marlene Wewalka, Donald C. We examined whether an intensive lifestyle intervention for weight loss would decrease cardiovascular morbidity and mortality among such patients. The American Journal of the Medical Sciences 351:4, 380-386. Mion, M. Two-sided P values were calculated with likelihood-ratio tests from Cox proportional-hazards regression, with models containing terms for clinical site, history of cardiovascular disease, and study-group assignment. ). Tylka. Patients could be using any type of glucose-lowering medication, but the percentage of those receiving insulin allowed in the trial was limited to less than 30%. At that time, the probability of observing a significant positive result at the planned end of follow-up (i. 2nd ed. 2016. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. CrossRef 79 I-Te Lee, Jun-Sing Wang, Chia-Po Fu, Shih-Yi Lin, Wayne Huey-Herng Sheu. Adobe Flash Player is required to view this feature. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Adobe Flash Player is required to view this feature. This site is best viewed in Internet Explorer 8 or later. Hofbauer, Sundeep Khosla, Beata Lecka-Czernik, Ann V. Pownall, Ashok Balasubramanyam, Jeanne M. (2016) Low Physical Activity Is Associated With Increased Arterial Stiffness in Patients Recently Diagnosed With Type 2 Diabetes. Hackett, Andrew Steptoe. Differences in mean weight loss were largest at 1 year (8. Source Information The authors and their affiliations are listed in the Appendix. (2016) Relative Importance of Fitness and Fatness in Obesity Intervention. CrossRef 142 Esben Vedel-Larsen, Eva Winning Iepsen, Julie Lundgren, Claus Graff, Johannes J. Lee. Clifton, N. ElHafeez, P. Provenzano, G. It was designed and conducted by the authors, and all analyses were completed by the coordinating center. This positive effect may explain why patients in the intervention group were less likely to be treated with insulin during this period. Tripepi, L. The study was approved by the institutional review board at each center. Adobe Flash Player is required to view this feature. (2016) Critical review: CPAP and weight management of obstructive sleep apnea cardiovascular co-morbidities. CrossRef 105 Arne Astrup, Beth Rice Bradley, J. Fenning. Patients with and those without a history of cardiovascular disease were included to increase the generalizability of the results. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. However, the study was not randomized, and the results achieved through surgery cannot be generalized to other methods of weight loss. Journal of Immigrant and Minority Health 18:2, 479-489. F. Stark. CrossRef 76 Brian Tomlinson, Miao Hu, Yuzhen Zhang, Paul Chan, Zhong-Min Liu. Shown are the changes from baseline in overweight or obese patients with type 2 diabetes who participated in an intensive lifestyle intervention (intervention group) or who received diabetes support and education (control group). Tapsell, Elizabeth P. The study center was included as a covariate, the covariance was unstructured, and linear contrasts were used to compare groups throughout follow-up. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. The study was sponsored by the National Institutes of Health, with additional support from other federal partners and the clinical research centers of several participating institutions. (2016) Validation of the Economic and Health Outcomes Model of Type 2 Diabetes Mellitus (ECHO-T2DM). Le Roux, C. H. Sassoon, Kieren J. Journal of Diabetes and its Complications 30:5, 935-943. Lister, J. Tuyeras, Y. (2016) Effects of gastric banding on glucose tolerance, cardiovascular and renal function, and diabetic complications: a 13-year study of the morbidly obese. Means were estimated with the use of generalized linear models for continuous measures. Methods Study Design The study methods have been published previously. Adobe Flash Player is required to view this feature. 00). CrossRef 57 Michael Willis, Pierre Johansen, Andreas Nilsson, Christian Asseburg. Physical and laboratory measurements and medication use from baseline through 10 years were modeled with generalized linear regression and generalized estimating equations. Kritchevsky,. (2016) BMI and mortality: the limits of epidemiological evidence. 4 years, when the last observed event occurred. Buitrago, Andrew S. Results Study Patients From August 2001 through April 2004, a total of 5145 patients were enrolled and randomly assigned to participate in the intensive lifestyle intervention (2570) or to receive diabetes support and education (2575) (Fig. Feher, D. These queries were augmented with searches of national databases for deaths. The average age was 58. 5% at the end. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Bellary, M. Singh, Alomgir Hossain, Ahmed Kotb, George A. S2 and S3 and Table S1 in the Supplementary Appendix ). Hompesch. (2016) Outcome studies and safety as guide for decision making in treating patients with type 2 diabetes. Adobe Flash Player is required to view this feature. A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD study. 0. K. Weight loss and mortality in persons with type-2 diabetes mellitus: a review of the epidemiological evidence. Jones, J. (2016) Testing the usefulness of the number needed to treat to be harmed (NNTH) in benefit-risk evaluations: case study with medicines withdrawn from the European market due to safety reasons. (2016) Impact of intensive lifestyle intervention on preference-based quality of life in type 2 diabetes: Results from the Look AHEAD trial. Verhoeven, Herman van Wietmarschen, Ruud Boessen, Linette P. (2016) Levels of the soluble LDL receptor-relative LR11 decrease in overweight individuals with type 2 diabetes upon diet-induced weight loss. Michel, C. Sijbrands, Monique T. Try these simple tips to get or stay fit in 2017. Primary prevention of cardiovascular disease with a Mediterranean diet. Siri-Tarino. (2016) Manipal diabetes coronary artery severity score. (2016) A physiological characterization of the Cafeteria diet model of metabolic syndrome in the rat. Means were estimated with the use of generalized linear models for continuous measures. L. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. The opinions expressed in this article are those of the authors and do not necessarily reflect the views of the funding sources. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2016) Managing dyslipidaemia in type 2 diabetes mellitus. The intensive lifestyle intervention also produced greater reductions in glycated hemoglobin and greater initial improvements in fitness and all cardiovascular risk factors, except for low-density-lipoprotein cholesterol levels. Adobe Flash Player is required to view this feature. (2016) Advances in Lipid Therapy: The Role of Lipid Treatment in Women in Primary Prevention. , the Mediterranean diet 18 ) might have different outcomes. CrossRef 155 K. Schneider, M. Obesity Management for the Treatment of Type 2 Diabetes. CrossRef 52 Ramon Casanova, Satoru Hayasaka, Santiago Saldana, Nick R. H. (2016) Evolution of pharmacological obesity treatments: focus on adverse side-effect profiles. CrossRef 135 Sudesna Chatterjee, Kamlesh Khunti, Melanie J. The finding that the intensive lifestyle intervention, as compared with diabetes support and education, did not reduce the risk of cardiovascular morbidity and mortality must be considered in the context of other positive effects observed with this intervention. (2017) Representation of people of South Asian origin in cardiovascular outcome trials of glucose-lowering therapies in Type 2 diabetes. (2016) Impact of Dietary and Metabolic Risk Factors on Cardiovascular and Diabetes Mortality in South Asia: Analysis From the 2010 Global Burden of Disease Study. CrossRef 11 Moul Dey. Wong, Eric Y. Adobe Flash Player is required to view this feature. CrossRef 100 Audrey Melvin, Carel W. CrossRef 139 Chrishan Joseph Nalliah, Prashanthan Sanders, Hans Kottkamp, Jonathan M. Schwartz. (2016) Comparative effectiveness of immunosuppressive drugs and corticosteroids for lupus nephritis: a systematic review and network meta-analysis. Heneghan, Jeffrey K. Citing Articles 1 Brian Tomlinson, Miao Hu, Yuzhen Zhang, Paul Chan, Zhong-Min Liu. Wadden. Fatuzzo, F. (2016) Continued efforts to translate diabetes cardiovascular outcome trials into clinical practice. Kovesdy, Susan Furth, Carmine Zoccali. Endocrinology and Metabolism Clinics of North America 45:3, 565-580. Shepherd, W. W. Hung, Tazeen Hasan Jafar, Meg Jardine, Vivekanand Jha, Linong Ji, Steven E. (2016) The relationship of social support with treatment adherence and weight loss in Latinos with type 2 diabetes. (2016) Health: a dream from reality to the future. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Gudzune. (2016) The role of obesity in atrial fibrillation. CrossRef 144 Oliver Schnell, Jianping Weng, Wayne H. Nilsson, Nick Finer, Wolfram Doehner. -S. Our findings showed that overweight or obese adults with type 2 diabetes can lose weight and maintain modest weight loss during a 10-year period. Greve. Pontiroli. Adobe Flash Player is required to view this feature. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2016) Metabolic Surgery for Type 2 Diabetes: Changing the Landscape of Diabetes Care. (2016) Lifestyle changes and cardiovascular risk reduction in diabetes. Abstract Background Weight loss is recommended for overweight or obese patients with type 2 diabetes on the basis of short-term studies, but long-term effects on cardiovascular disease remain unknown. Clark,. Thus, the results cannot be generalized to all patients with type 2 diabetes. Nauck. Adobe Flash Player is required to view this feature. A. Kashyap. Ehrman, Mouaz H. Wan, Anca K. Nilsson. Laurienti. CrossRef 39 Jennifer Collins, Chelsea Meng, Anna Eng. CrossRef 125 Suryun Jung, Sangbok Moon, Kijin Kim. Inge. Lee, K. In addition, we recruited patients with type 2 diabetes who were motivated to lose weight through lifestyle intervention and who could successfully complete a maximal-fitness test at baseline. , and Richard S. (2016) Sodium-glucose cotransporter 2 inhibitors and cardiovascular outcomes. Wilkins, Regis R. Bain, M. (2016) Effect of different intensities of physical activity on cardiometabolic markers and vascular and cardiac function in adult rats fed with a high-fat high-carbohydrate diet. Third, the provision of educational sessions and the increased use of statins in the control group, as compared with the intervention group, may have lessened the difference between the two groups. Vacheron. (2016) Randomized controlled trial of a nationally available weight control program tailored for adults with type 2 diabetes. Aucella, S. Zoccali. Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial. CrossRef 114 Hyunsung Oh, Kathleen Ell. Midcourse correction to a clinical trial when the event rate is underestimated: the Look AHEAD (Action for Health in Diabetes) Study. Tomolo, Usha Ramakrishnan, K. The median duration of diabetes was 5 years, and 14% of patients reported a history of cardiovascular disease. (2017) A meta-analysis comparing clinical effects of short- or long-acting GLP-1 receptor agonists versus insulin treatment from head-to-head studies in type 2 diabetic patients. (2016) Impact of Intragastric Balloon Before Laparoscopic Gastric Bypass on Patients with Super Obesity: a Randomized Multicenter Study. (2016) Post-marketing withdrawal of anti-obesity medicinal products because of adverse drug reactions: a systematic review. Adobe Flash Player is required to view this feature. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults -- the evidence report. De Paola, L. 5 years. M. Escourrou, G. The primary outcome was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for angina. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. During annual visits and telephone calls every 6 months, staff members who were unaware of study-group assignments queried patients about all medical events and hospitalizations. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. Bibus, K. Adobe Flash Player is required to view this feature. Poulsen. CrossRef 25 Satya Dash. The reported main effect is the average of all between-group differences after baseline. The inset shows the same data on an expanded y axis. CrossRef 156 Ping Zhang, Don Hire, Mark A. Study Interventions Eligible patients were randomly assigned to participate in an intensive lifestyle intervention (intervention group) or to receive diabetes support and education (control group), with stratification according to clinical site. (2016) Feeling the pressure: (patho) physiological mechanisms of weight gain and weight loss in humans. Bray, MD: Progress in Obesity—Multidisciplinary Research, Multidimensional Man. The authors vouch for the accuracy and completeness of the data and all analyses and for the fidelity of this report to the trial protocol, available at NEJM. Cardiovascular events after bariatric surgery in obese subjects with type 2 diabetes. CrossRef 34 Christoffer Martinussen, Kirstine Nyvold Bojsen-Moller, Maria Saur Svane, Thomas Fremming Dejgaard, Sten Madsbad. K. Davies. org). At a median follow-up of almost 10 years, there was no significant difference between the two groups in cardiovascular morbidity and mortality. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Handbook of obesity: clinical applications. 5% in the control group. R. CrossRef 126 Anawin Sanguankeo, Mariana Lazo, Sikarin Upala, Frederick L.
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CrossRef 51 Mariana Gomez-Smith, Sudhir Karthikeyan, Matthew S. The reported main effect is the average of all between-group differences after baseline. CrossRef 27 J. Wells. Achievement of goals in U. Enroll in the Living WIth Type 2 Diabetes Program. e. Joseph, Sherita Hill Golden. CrossRef 13 Longo, Dan L. Msika. -M. Wierzbicki. Zakaria, Luca Rossetti, Maurizio Cristina, Anna Veronelli, Federico Lombardi, Alessandro Saibene, Giancarlo Micheletto, Antonio E. Venkat Narayan, Lawrence S. 0 (Insightful), or SAS software, version 9. In addition, the intensification of medical management of cardiovascular risk factors 17 in routine medical care in the two study groups may have made the relative benefit of the intensive lifestyle intervention more difficult to demonstrate. (2017) DYNAMIC INTERACTIONS OF n-3 AND n-6 FATTY ACID NUTRIENTS. (2017) Physical inactivity: a risk factor and target for intervention in renal care. Intentional weight loss and mortality among overweight individuals with diabetes. (2017) A Clinical Practice Lifestyle Intervention for Type 2 Diabetes. All statistical analyses were conducted with the use of S-Plus software, version 8. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. The intensive lifestyle intervention was aimed at achieving and maintaining weight loss of at least 7% by focusing on reduced caloric intake and increased physical activity. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. The Swedish Obese Subjects (SOS) study 5 showed reduced rates of cardiovascular events during a mean follow-up of 13. 0. CrossRef 54 David W. In this regard, it is noteworthy that the differential weight loss between the two trial groups averaged 4% over the course of the study but only 2. le Roux, Neil G. Kim, D. Curricula for the two study groups were developed centrally and have been described in detail previously 6,8 (see the Supplementary Appendix ). If you are using an operating system that does not support Flash, we are working to bring you alternative formats. S. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2016) Healthy ageing: Evidence that improvement is possible at every age. (2017) Cardiovascular consequences of metabolic syndrome. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Flum. Bertoni. Adobe Flash Player is required to view this feature. Barrett, Arthur Weltman. (2016) Obesity Prevention in Older Adults. Riella, Elena Zakharova. Kalman. (2016) Emerging drugs for the treatment of obesity. Reviews in Endocrine and Metabolic Disorders 17:1, 117-127. J. W. (2016) Effect of weight loss induced by energy restriction on measures of arterial compliance: A systematic review and meta-analysis. Kelly, Thomas H. This article was published on June 24, 2013, and updated on May 8, 2014, at NEJM. We acknowledge the contributions of the late Drs. (2016) Practical Approaches to Prescribing Physical Activity and Monitoring Exercise Intensity. CrossRef 70 (2016) Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial. There were no significant interactions among the prespecified subgroups ( Figure 3 Figure 3 Primary Outcome in Prespecified Subgroups. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Weight, Waist Circumference, and Fitness Patients in the intervention group had significantly greater reductions in weight and waist circumference and greater improvement in fitness than did those in the control group ( Figure 1A, 1B, and 1C Figure 1 Changes in Weight, Physical Fitness, Waist Circumference, and Glycated Hemoglobin Levels during 10 Years of Follow-up. Rapana, A. (2016) Major adverse cardiovascular events with basal insulin peglispro versus comparator insulins in patients with type 1 or type 2 diabetes: a meta-analysis. Journal of the American College of Cardiology 68:23, 2497-2504. (2016) Type 2 Diabetes Treatment in the Patient with Obesity. Arnold, Mark A. 2017. Hospital and other records were reviewed for potential cardiovascular events, with adjudication according to standard criteria by reviewers who were unaware of study-group assignments (see the Supplementary Appendix ). CrossRef 90 Naji Alamuddin, Thomas A. , are deceased. Diabetes Mellitus in Developing Countries and Underserved Communities, 251-284. 2016. Lamberts. Full Text of Methods. Cefalu, Francesco Rubino, David E. 2 National Institutes of Health. 6% in the intervention group vs. CrossRef 15 Wenmao Yan, Rixing Bai, Ming Yan, Maomin Song. CrossRef 75 Diogo Mendes, Carlos Alves, Francisco Batel Marques. (2016) Gastric Bypass Surgery Leads to Long-term Remission or Improvement of Type 2 Diabetes and Significant Decrease of Microvascular and Macrovascular Complications. CrossRef 21 K. Espeland,. Adobe Flash Player is required to view this feature. (2016) Fitness, Fatness, and Mortality: The FIT (Henry Ford Exercise Testing) Project. Sora. New York: Marcel Dekker, 2004:226-58. Adobe Flash Player is required to view this feature. Schauer, Geltrude Mingrone, Sayeed Ikramuddin, Bruce Wolfe. Disclosure forms provided by the authors are available with the full text of this article at NEJM. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2016) Management of type 2 diabetes: the current situation and key opportunities to improve care in the UK. Lifestyle modification for obesity: new developments in diet, physical activity, and behavior therapy. Crow, M. CrossRef 61 Na Wang, Jin-Ping Zhang, Xiao-Yan Xing, Zhao-Jun Yang, Bo Zhang, Xin Wang, Wen-Ying Yang. org. Steinberg. Neale. Messa, L. (2016) A weight-neutral versus weight-loss approach for health promotion in women with high BMI: A randomized-controlled trial. Thus, a critical question remains: Would an intensive lifestyle intervention designed to achieve weight loss through caloric restriction and increased physical activity decrease cardiovascular morbidity and mortality among overweight or obese adults with type 2 diabetes. Baseline characteristics of the randomised cohort from the Look AHEAD (Action for Health in Diabetes) study. The inset shows the same data on an expanded y axis. (2017) The Lifestyle Intervention for the Treatment of Diabetes study (LIFT Diabetes): Design and baseline characteristics for a randomized translational trial to improve control of cardiovascular disease risk factors. Al-Mallah. Davis, Nicket Dedhia, Jack A. Bhat, Poornima A Manjrekar, Chakrapani Mahabala. Adobe Flash Player is required to view this feature. org. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Keogh. -P. (2016) Nutrition in Type 2 Diabetes and the Metabolic Syndrome. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. The consistency of intervention effects on the primary outcome among three prespecified subgroups (based on sex, race or ethnic group, and presence or absence of cardiovascular disease at baseline) was evaluated with the use of interaction tests. Adobe Flash Player is required to view this feature. CrossRef 136 Auryan Szalat, Ronen Durst, Eran Leitersdorf. Adobe Flash Player is required to view this feature. Adobe Flash Player is required to view this feature. Enroll in the Living WIth Type 2 Diabetes Program. Simonson, Ann Goebel-Fabbri, Kathleen Foster, Florencia Halperin, Ashley Vernon, Allison B. CrossRef 127 A. (2016) Dietary and Behavioral Approaches in the Management of Obesity. 6 years (interquartile range, 8. CrossRef 119 June Stevens, Eva Erber-Oakkar, Zhaohui Cui, Jianwen Cai, Salim S. However, our trial was planned to test the effects of an intensive lifestyle intervention, and the weight loss achieved in the intervention group is representative of the best that has been achieved with current lifestyle approaches. Nearly 30 million battle diabetes and every 23 seconds someone new is diagnosed. Study End Points The primary end point was the first occurrence of a composite cardiovascular outcome. Pipe. Mechanick. Results were not adjusted for multiple comparisons, and a P value of less than 0. (2016) Nutrition in Diabetes. M. Verhoeven, Hideaki Bujo, Eric J. D. Sijbrands, Joseph Devaney. CrossRef 37 Hans Hauner. (2016) The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight. 6,7 The study was conducted at 16 clinical sites in the United States (for details, see the Supplementary Appendix, available with the full text of this article at NEJM. Khunti, S. The primary outcome was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for angina during a maximum follow-up of 13. Veliko, Nicoleta D. (2016) Association between anorexia nervosa and type 2 diabetes in Sweden: Etiological clue for the primary prevention of type 2 diabetes. (2016) Predictors of Diet-Induced Weight Loss in Overweight Adults with Type 2 Diabetes. Diabetes causes more deaths a year than breast cancer and AIDS combined. CrossRef 30 B. CrossRef 31 Andres Acosta, Michael Camilleri. Your gift today will help us get closer to curing diabetes and better treatments for those living with diabetes. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. CrossRef 108 Carlos K. CrossRef 160 Ronald CW Ma. Bakker, Eva Corpeleijn, Gerjan Navis. Aronson. (2016) The EMPA-REG outcome study: critical appraisal and potential clinical implications. Shown are the changes from baseline in overweight or obese patients with type 2 diabetes who participated in an intensive lifestyle intervention (intervention group) or who received diabetes support and education (control group). Lands, D. (2017) Persistent organic pollutants in adipose tissue should be considered in obesity research. Lifestyle change and mobility in obese adults with type 2 diabetes. Journal of the American Geriatrics Society 65:1, 137-145. Adobe Flash Player is required to view this feature. Malin, Sangeeta R. 5% at the end of the trial. -H. Khunti. It is unclear whether an intervention focused on changes in dietary composition (e. CrossRef 41 S. (2016) Colchicine to decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation. Adobe Flash Player is required to view this feature. Clinical Journal of the American Society of Nephrology 11:3, 528-535. CrossRef 4 Y. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2016) Assessing the evidence: Exploring the effects of exercise on diabetic microcirculation. Chan, Frank W. Sheu, Hirotaka Watada, Sanjay Kalra, Sidartawan Soegondo, Noriyuki Yamamoto, Rahul Rathod, Cheryl Zhang, Wladyslaw Grzeszczak. CrossRef 161 Avivit Cahn, Simona Cernea, Itamar Raz. Yanovski. The control group had a gradual but consistent weight loss throughout the study, resulting in an average weight loss of 3. (2016) Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes. Zuccala, G. Additional baseline data have been published previously. 82 in the intervention group) was estimated to be 1%. The dashed vertical line indicates the overall hazard ratio (0. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. 7% in the control group) but remained significant throughout the trial. Wong, William C. CrossRef 47 Kimberly Gudzune. (2017) A Working Paradigm for the Treatment of Obesity in GI Practice. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2016) Cardiovascular disease risk by assigned treatment using the 2013 and 1998 obesity guidelines. Adobe Flash Player is required to view this feature. The Look AHEAD (Action for Health in Diabetes) researchers addressed this question in a multicenter, randomized clinical trial. 05 was considered to indicate statistical significance. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it. Gray, P. Schneider, Reinier Timman, Adrie J. Patel, V. CrossRef 97 Boris Hansel, Dominique Bonnefont-Rousselot, Alexina Orsoni, Randa Bittar, Philippe Giral, Ronan Roussel, Michel Marre, Kamel Mohammedi, Eric Bruckert, Martin John Chapman, Anatol Kontush. (2016) Psychological Impact of Severe Obesity. Glick,. Russell-Jones, K. (2016) Moving the goalposts - towards cardiovascular prevention. Adobe Flash Player is required to view this feature. Risk Factors for Cardiovascular Disease During the first year of follow-up, patients in the intervention group had greater improvements than the control group in glycated hemoglobin levels ( Figure 1D ) and in all other measured cardiovascular risk factors, except for low-density lipoprotein (LDL) cholesterol levels (Fig. M. Bonanno, P. Submaximal-exercise tests were performed in the full cohort at years 1 and 4 and in a subset of patients at year 2. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. A. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. (2016) Acarbose reduces body weight irrespective of glycemic control in patients with diabetes: results of a worldwide, non-interventional, observational study data pool. (2016) Gastric bypass surgery vs intensive lifestyle and medical intervention for type 2 diabetes: the CROSSROADS randomised controlled trial. CrossRef 18 Rhodri J King, Ramzi A Ajjan. To prevent and cure diabetes and to improve the lives of all people affected by diabetes. Ledoux, F. CrossRef 48 Angelo Avogaro, Gian Paolo Fadini, Giorgio Sesti, Enzo Bonora, Stefano Del Prato. (2016) Reduced Cardiovascular Disease Incidence With a National Lifestyle Change Program. The numbers below the graph are the numbers of patients at risk in each study group at years 2, 4, 6, and 8 and at 10. Adobe Flash Player is required to view this feature. (2016) Cardiovascular effects of bariatric surgery. CrossRef 140 Helmut O. 14 Wadden TA, Webb VL, Moran CH, Bailer BA. Adobe Flash Player is required to view this feature. (2016) Behavioral Treatment of the Patient with Obesity. G. Alexandria, VA: American Diabetes Association, 2013. The program included both group and individual counseling sessions, occurring weekly during the first 6 months, with decreasing frequency over the course of the trial. Noel Bairey Merz. CrossRef 74 Helena Lenasi, Markos Klonizakis. CrossRef 45 Gianluca Perseghin, Anna Solini. CrossRef 159 Becky Marquez, Andrea Anderson, Rena R. Disse, J. Thomason, Bojana Stefanovic, Dale Corbett. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Adobe Flash Player is required to view this feature. Lifestyle Issues: Diet. S. (2016) Body mass index and mortality in patients with type 2 diabetes mellitus: A prospective cohort study of 11,449 participants. (2016) Multifactorial intervention in diabetes care using real-time monitoring and tailored feedback in type 2 diabetes. Adobe Flash Player is required to view this feature. M. The primary outcome was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for angina. (2016) Effects of visceral adipose tissue reduction on CVD risk factors independent of weight loss: The Look AHEAD study. Docherty. D. Fabrizi, P. CrossRef 118 Frank L. CrossRef 81 Hui Liu, Shouling Wu, Yun Li, Lixia Sun, Zhe Huang, Liming Lin, Yan Liu, Chunpeng Ji, Hualing Zhao, Chunhui Li, Lu Song, Hongliang Cong. CrossRef 133 Stella Lucia Volpe, Deeptha Sukumar, Brandy-Joe Milliron. Adobe Flash Player is required to view this feature. Dreux, A. (2016) Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes. Your tax-deductible gift today can fund critical diabetes research and support vital diabetes education services that improve the lives of those with diabetes. Intensive lifestyle intervention improves physical function among obese adults with knee pain: findings from the Look AHEAD trial. (2016) Benefits of commercial weight-loss programs on blood pressure and lipids: a systematic review. CrossRef 16 Nancy Tarr Anderson, Ellen P. Nasrallah, Thomas Wadden, Paul J. Mather. Arvieux, P. Causes of Severe Obesity: Genes to Environment. Rastelli, F. Hudgel. (2016) Optimizing management of glycaemia. (2017) Mechanisms, Pathophysiology, and Management of Obesity. Furth, Carmine Zoccali, Philip Kam Tao Li, Guillermo Garcia-Garcia, Mohammed Benghanem-Gharbi, Rik Bollaert, Sophie Dupuis, Timur Erk, Kamyar Kalantar-Zadeh, Csaba Kovesdy, Charlotte Osafo, Miguel C. Goldfine. diabetes care, 1999-2010. CrossRef 80 Jianguang Ji, Jan Sundquist, Kristina Sundquist. (2016) Lifestyle intervention enhances high-density lipoprotein function among patients with metabolic syndrome only at normal low-density lipoprotein cholesterol plasma levels. Adobe Flash Player is required to view this feature. The characteristics of the patients in the two groups were similar at baseline ( Table 1 Table 1 Characteristics of the Patients at Baseline. CrossRef 36 Nicola Guess. The numbers below the graph are the numbers of patients at risk in each study group at years 2, 4, 6, and 8 and at 10. Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: design and methods. (2016) Associations between changes in glucagon-like peptide-1 and bodyweight reduction in patients receiving acarbose or metformin treatment. F. A review and meta-analysis of the effect of weight loss on all-cause mortality risk. (2016) Update on Youth-Onset Type 2 Diabetes. Hanif,. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. CrossRef 152 Rong Chen, Bruce Ovbiagele, Wuwei Feng. Adobe Flash Player is required to view this feature. (2016) The Effect of Interdisciplinary Interventions on Risk Factors for Lifestyle Disease. Adobe Flash Player is required to view this feature. 95), and the solid vertical line indicates no effect (hazard ratio, 1. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. McCalla, Patrice G. The Indian Health Service (IHS) provided personnel, medical oversight, and use of facilities. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Journal of Diabetes and its Complications 30:4, 628-637. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Fujioka, M. 2016. Mulder. (2016) Joint statement of the European Association for the Study of Obesity and the European Society of Hypertension. Shown are hazard ratios for three prespecified subgroups — defined according to the presence or absence of cardiovascular disease at baseline, sex, and race or ethnic group — in the intervention group and the control group. The trial was not blinded, but clinical assessors and end-point adjudicators were unaware of study-group assignments. Pellis, Adriaan van t Spijker, Reinier Timman, Behiye Ozcan, Eric J. S2 and Table S1 in the Supplementary Appendix ). 0% in the intervention group and 3. (2016) The Role of Macronutrient Content in the Diet for Weight Management. (2016) Relative differences in resting-state brain connectivity associated with long term intensive lifestyle intervention. Calogero, Saverio Stranges, Tracy L. Chan, Cindy L. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Adobe Flash Player is required to view this feature. Endocrinology and Metabolism Clinics of North America 45:4, 799-817. Archives des Maladies du Coeur et des Vaisseaux - Pratique 2016:252, 10-12. M. Meier, Michael A. Adobe Flash Player is required to view this feature. Powles, Majid Ezzati, Dariush Mozaffarian,. (2017) Toward a Personalized Approach in Prebiotics Research. The intervention group also had greater improvements in fitness, particularly at 1 year. Mulder, Adrie J. We thank the Bureau of Vital Statistics of the New York City Department of Health and Mental Hygiene for providing data used in the study. Battaglia, R. Pownall, Jessica Unick, Thomas Wadden, Lynne Wagenknecht,. Specific intervention strategies included a calorie goal of 1200 to 1800 kcal per day (with 15% from protein), the use of meal-replacement products, and at least 175 minutes of moderate-intensity physical activity per week. Methods In 16 study centers in the United States, we randomly assigned 5145 overweight or obese patients with type 2 diabetes to participate in an intensive lifestyle intervention that promoted weight loss through decreased caloric intake and increased physical activity (intervention group) or to receive diabetes support and education (control group). Krentz, K. -H. Surgery for Obesity and Related Diseases 12:3, 587-595. When the study ended, the mean weight loss from baseline was 6. CrossRef 46 Osama Hamdy, Mohd-Yusof Barakatun-Nisak. S. Saab. (2016) Psychosocial Factors in Diabetes and Cardiovascular Risk. Coupaye, S. Obesity and Diabetes. Frederick Brancati and Richard Rubin to the successful development and execution of this trial. We used a specific lifestyle intervention that focused on achieving weight loss through caloric restriction and increased physical activity. CrossRef 35 Peter M. Broyles, Martha Walker, Gina Evans-Hudsnall,. Discussion In this study, we compared the effect of an intensive lifestyle intervention with a control regimen of diabetes support and education among overweight or obese patients with type 2 diabetes. (2017) Liraglutide for weight management: benefits and risks. (2016) Depression remission, receipt of problem-solving therapy, and self-care behavior frequency among low-income, predominantly Hispanic diabetes patients. Patients in the intervention group had clinically meaningful improvements in glycated hemoglobin levels, which were greatest during the first year but were at least partly sustained throughout follow-up.
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